I have also worked to translate scientific findings into real world impact using digital methods. This work from the bench led to innovative new technologies in outcomes assessments in preclinical models of neurological disease; my work was the primary subject of a report in Nature describing the impact of these tools for preclinical science.

I started my company, ConductScience.com (subsidiaries of mazeengineers.com and qolty.com), in 2013 while in medical school. ConductScience.com provides next generation scientific tools using novel technologies including artificial intelligent mazes, digital health apps, vision tracking, virtual reality, drones, and more. The company has been featured in Nature, Huffington Post, Popular Science, Discover Magazine, NPR, and the tools have been used and cited in manuscripts published in Nature and the Proceedings of the National Academy of Sciences. The company is a supplier at over 500 universities and private pharmaceutical companies worldwide and with international distribution in over 40 countries.

1. 1. Choi C. The mazes with minds of their own. Nature. 2018.

My career focus has been the acute management of neurological disease with novel therapies and protocols. I have written extensively of novel agents and their effects as well as effects of interventions on outcomes beyond traditional morbidity and mortality including patient reported outcomes and health related quality of life. A few select publications:

1. 1. He S, Mack WJ  Perspectives: health related quality of life following aneurysmal subarachnoid hemorrhage: interplay between physical, cognitive and emotional factors. World Neurosurg. 2013 Jan 16.
   2. Adamczyk P, He S, Amar A, Mack W. Medical Management of Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage: A Review of Current and Emerging Therapeutic Interventions. Neurology Research International. 2013
   3. Belur PK, Chang J,  He S , Emanuel B, Mack W. Emerging Experimental Therapies for Intracerebral Hemorrhage: Targeting Mechanisms of Secondary Brain Injury. Neurosurgical Focus. May 2013.
   4. He S, Mack WJ, Considering Radiation Exposure During Diagnostic and Therapeutic Procedures for Arteriovenous Malformations in the Setting of Pregnancy. World Neurosurg. Feb 2013.

In addition to studying the management of acute neurological emergencies for individual patients, I have looked at macro trends in hospitalizations in order to understand both regionalization of care and variances in interventions based on volume of location of the center.

1. 1. Lucas Ramirez, May Kim-Tenser, Nerses Sanossian, Steven Cen, Ge Wen, Shuhan He, William Mack, and Amytis Towfighi. Trends in Acute Ischemic Stroke Hospitalizations in the United States. J Am Heart Assoc. May 11, 2016;
   2. Hanks N, Wen G, He S, Song S, Saver JL, Cen S, Kim-Tenser M, Mack WJ, Sanossian N: Expansion of Emergency Medical Service Regional Routing for Stroke Patient Care from 2000-2010. Western Journal of Emergency Medicine, EPub April 16, 2014
   3. Adamczyk P, Attenello F, Wen G, He S, Russin J, Sanossian N, Amar AP, Mack WJ. Mechanical Thrombectomy in Acute Stroke: Utilization Variances and Impact of Procedural Volume on Inpatient Mortality. Journal of Stroke and Cerebrovascular Diseases.  Nov 2013.

I have done work in preclinical models of neurological disease as well for understanding fundamental mechanisms of the complex interplay between the brain and the immune system. I have worked with murine models of ischemic stroke and shown subtle cognitive change using novel methodologies in behavioral testing, akin to patient reported outcomes in the preclinical stage for improved translational therapies to the bedside.

1. 1. Liu Q. He S, Scotton T, Shaked D, Cen Y, Mack WJ. C5 Complement Modulation in Attenuates Ischemic White Matter Injury Following Experimental Chronic Cerebral Hypoperfusion. PLoS One. 2013
   2. He S, Pham MH, Pease M, Zada G, Gionnotta SL, Wang K, Mack WJ.A Review of Epigenetic and Gene Expression Alterations Associated with Intracranial Meningiomas. Neurological Focus. Sept 2013.
   3. Liu Q, Babadjouni R, Radwanski R, Cheng H, Patel A, Hodis DM, He S, Baumbacher P, Russin JJ, Morgan TE, Sioutas C, Finch CE, Mack WJ. Stroke Damage Is Exacerbated by Nano-Size Particulate Matter in a Mouse Model. PLoS One. 2016 Apr 12;11(4):e0153376. doi: 10.1371/journal.pone.0153376. eCollection 2016
   4. Mehta V, Russin J, Spirtos A, He S,  Adamczyk P, Amar A, Mack W. Matrix Metalloproteinases in Cerebral Vasospasm following Aneurysmal Subarachnoid Hemorrhage. Neurology Research International, vol. 2013. 2013.

My work has also looked into the access and disparities for patients in obtaining care for acute neurological emergencies across both socioeconomic and racial lines.

Adamczyk P, Attenello F, Wen G, He S, Russin J, Sanossian N, Amar AP, Mack WJ. Racial and Socioeconomic Disparities in Access to Mechanical Revascularization Procedures for Acute Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases. 2013

Wen T, Attenello FJ, He S, Cen Y, Kim-Tenser MA, Sanossian N, Amar AP,  Mack WJ. Racial and Socioeconomic Disparities in Incidence of Hospital Acquired Complications Following Cerebrovascular Procedures. Neurosurgery 2014.

Attenello FJ, Adamczyk P, Wen G, He S, Russin JJ, Sanossian N, Amar AP, Mack WJ. Racial and Socioeconomic Disparities in Access to Mechanical Revascularization Procedures for Acute Ischemic Stroke. Journal of Stroke and Cerebrovascular Diseases. February 2014.